Troubleshooting: This application is not allowed to change its authentication preferences unless QuickBooks is running with the Administrator logged in

Problem Description:

IsAService: False

Begin Session Failed. S0000 00000 [QODBC] QB Begin Session Failed. Error = 80040421, This application is not allowed to change its authentication preferences unless QuickBooks is running with the Administrator logged in.

Begin Session errors can be caused when running ASP or other system service and not setting the "Advanced" button option of either "Use DCOM Servers" or "Remote Connector."

Begin Session Failed. S0000 00000 [QODBC] QB Begin Session Failed. Error = 80040421, This application is not allowed to change its authentication preferences unless QuickBooks is running with the Administrator logged in.

0x00000000 [ISAM] S0000 00000 [QODBC] QB Begin Session Failed. Error = 80040421, This application is not allowed to change its authentication preferences unless QuickBooks is running with the Administrator logged in.

ISAM_BEGINSESSIONFAIL S0000 00000 [QODBC] QB Begin Session Failed. 

Solution:

Please start QuickBooks, log in to the company file as Admin, and Switch QuickBooks to single-user mode.

Try connecting your application. It should pop up Data Access Certificate on QuickBooks. Please accept the Certificate.

After the Certificate is accepted, Please close your application and Switch QuickBooks to Multi-User Mode.

Perform a test with your application.

If the above does not resolve the issue, Please start QuickBooks, log in as Admin, and Switch QuickBooks to single-user mode.

Try removing "Flexquarters QODBC " from the Integration Application

Refer to: How to remove QODBC Related Certificates from Integrated Application Under QuickBooks

And try again with your application.